解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Candida antarctica Lipase B (CALB) was covalently immobilized onto epoxy-activated macroporous poly(methyl methacrylate) Amberzyme beads (235 microm particle size, 220 A pore size) and nanoparticles (nanoPSG, diameter 68 nm) with a poly(glycidyl methacrylate) outer region. Amberzyme beads allowed CALB loading up to 0....
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700949x
更新日期:2008-02-01 00:00:00
abstract::It was aim of the study to investigate the in vivo potential of a novel insulin-thiomer complex nanoparticulate delivery system. Insulin loaded nanoparticles were obtained by the formation of hydrogen bonds between poly(vinyl pyrrolidone) (PVP) and poly(acrylic acid)-cysteine (PAA-Cys) or poly(acrylic acid) (PAA), res...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700916h
更新日期:2008-01-01 00:00:00
abstract::Structural properties of different polypeptide multilayer nanofilms fabricated at neutral pH have been analyzed by UV spectroscopy, circular dichroism spectroscopy (CD), and Fourier-transform infrared spectroscopy (FTIR). The various peptides studied exhibit a strong tendency to adopt a beta sheet conformation in the ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700967k
更新日期:2008-01-01 00:00:00
abstract::Presently there is great interest in the construction of nanostructures from DNA fragments. Here we report the preparation of much larger helical textures with different shapes from pure DNA fragments. We have observed them while preparing crystals of the dodecamer d(AAAAAATTTTTT), which only contains adenine and thym...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700994v
更新日期:2008-01-01 00:00:00
abstract::Ephemeral gels, called Enzgels, successively undergo sol-gel and then gel-sol transition under the action of two antagonistic enzymes, transglutaminase and protease. Molecular and macroscopic properties of Enzgels are directly dependent on the enzymatic activities and their ratios. This work studies the characteristic...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700601n
更新日期:2008-01-01 00:00:00
abstract::Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700906k
更新日期:2008-01-01 00:00:00
abstract::Protein polymers (long-chain proteins in which a specific amino acid sequence "monomer" is repeated through the molecule) are found widely in nature, and these materials exhibit a diverse array of physical properties. One class of self-assembling proteins is hydrophobic-polar (HP) protein polymers capable of self-asse...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701131x
更新日期:2008-01-01 00:00:00
abstract::PolyHIPEs show great promise as tissue engineering scaffolds due to the tremendous control of pore size and interconnectivity afforded by this technique. Highly porous, fully biodegradable scaffolds were prepared by polymerization of the continuous phase of high internal phase emulsions (HIPEs) containing the macromer...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7007235
更新日期:2007-12-01 00:00:00
abstract::This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700762w
更新日期:2007-12-01 00:00:00
abstract::Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) ( pOEGMA) with various thicknesses were formed on gold and Si/SiO 2 substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester-an initiator of atom transfer radical polymerization (...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7009043
更新日期:2007-12-01 00:00:00
abstract::Polystyrene-polyisocyanopeptide (PS-PIAT) polymersomes containing CALB in two different locations, one in the aqueous inner compartment and one in the bilayer, were investigated for enzymatic ring-opening polymerization of lactones in water. It is shown that the monomers 8-octanolactone and dodecalactone yield oligome...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7005938
更新日期:2007-12-01 00:00:00
abstract::We report structural and dynamical aspects of DNAs from various sources including synthetic oligonucleotides in bulk buffer and as a complex with histone1 (H1). High-resolution transmission electron microscopic (HRTEM) studies reveal the structural change of the DNAs upon complexation with H1 leading to formation of c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700690p
更新日期:2007-11-01 00:00:00
abstract::We report the synthesis of PEG-coated, core-cross-linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The block copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescen...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7005399
更新日期:2007-11-01 00:00:00
abstract::The molecular recognition features of a DNA-sensitive fluorescent bioconjugate capable of targeting a specific DNA sequence with high efficiency are described. The bioconjugate combines a polypeptide from the Tc3 transposase DNA-binding domain with the dsDNA-sensitive fluorophore thiazole orange. Fluorescence spectros...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070334h
更新日期:2007-11-01 00:00:00
abstract::Our previous studies have demonstrated the efficacy of generation 5 poly(amidoamine) dendrimers (G5-PAMAM) as a platform for the targeted delivery of chemotherapeutics. However, anticancer therapy can be subverted by anti-apoptotic changes in cancer cells. Bcl-2 and several of its peptides are commonly overexpressed i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700727g
更新日期:2007-10-01 00:00:00
abstract::The synthesis of poly(methyl methacrylate-co-methacryloxysuccinimide-graft-poly(ethylene glycol)) (PMMA-co-PMASI-g-PEG) via living free radical polymerization provides a convenient route to well-defined amphiphilic graft copolymers having a controllable number of reactive functional groups, variable length PEG grafts,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700541e
更新日期:2007-10-01 00:00:00
abstract::Chitosan is a linear cationic biopolymer composed of glucosamine and N-acetyl-glucosamine that is only soluble in acidic aqueous solutions and precipitates when neutralized. However, it was recently discovered that chitosan dissolved in solutions containing glycerol phosphate was soluble at near neutral pH and produce...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700520m
更新日期:2007-10-01 00:00:00
abstract::In this paper we report on protein refolding by means of a liquid-liquid transfer technique using a calixarene. We have found that a calix[6]areneacetic acid derivative forms a supramolecular complex with urea-denatured cytochrome c at the oil-water interface, which enables quantitative transfer of the protein from an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070418q
更新日期:2007-10-01 00:00:00
abstract::Ionic liquids (ILs) are composed only of ions. Of special interest to this review are those where at least one ion (the cation) is organic and whose melting points are below or not far above room temperature. ILs are designated as "green" solvents because they have extremely low vapor pressure, are non-inflammable, an...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/bm070062i
更新日期:2007-09-01 00:00:00
abstract::Ruthenium(II) tris(bipyridine)-centered poly(ethylenimine) (Ru PEI) was synthesized via acid hydrolysis of Ru tris(bipyridine)-centered poly(2-ethyl-2-oxazoline) (Ru PEOX), and the luminescence, DNA entrapment, and transfection efficiencies were evaluated. Emission maxima for Ru PEI samples are red-shifted compared to...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700481h
更新日期:2007-09-01 00:00:00
abstract::A temperature-responsive hydrogel composed of aqueous methylcellulose (MC) blended with distinct concentrations of PBS was prepared and characterized. The developed MC hydrogel underwent a sol-gel reversible transition upon heating or cooling at approximately 32 degrees C. This temperature-responsive hydrogel was empl...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0704166
更新日期:2007-09-01 00:00:00
abstract::Chitin is a nitrogen-rich polysaccharide that is abundant in crustaceans, mollusks, insects, and fungi and is the second most abundant organic material found in nature next to cellulose. Chitosan, the N-deacetylated derivative of chitin, is environmentally friendly, nontoxic, biodegradable, and antibacterial. Fibrous ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7006983
更新日期:2007-09-01 00:00:00
abstract::Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) was applied to investigate the interaction of bovine serum albumin (BSA) and fibrinogen with a biomedical-grade 316LVM stainless steel surface, in terms of the adsorption thermodynamics and adsorption-induced secondary structure changes of ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070289d
更新日期:2007-09-01 00:00:00
abstract::We describe a facile method to amine functionalize and subsequently fluorescently label polymethacrylamides synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT-generated poly(N-(2-hydroxypropyl) methacrylamide-b-N-[3-(dimethylamino)propyl] methacrylamide) (poly(HPMA-b-DMAPMA)),...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700514q
更新日期:2007-08-01 00:00:00
abstract::Light-harvesting antenna core (LH1-RC) complexes isolated from Rhodoseudomonas palustris were self-assembled on a gold electrode modified with self-assembled monolayers (SAMs) of the alkanethiols NH2(CH2)nSH, n = 2, 6, 8, 11; HOOC(CH2)7SH; and CH3(CH2)7SH, respectively. Adsorption of the LH1-RC complexes on the SAMs d...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070352z
更新日期:2007-08-01 00:00:00
abstract::Micellar peroxidase-catalyzed synthesis of chiral polyaniline (PANI) in the presence of dodecylbenzenesulfonic acid (DBSA) was developed. The effect of DBSA concentration on the catalytic efficiency of horseradish and palm tree peroxidases was examined. Favorable conditions for the enzymatic synthesis of chiral PANI, ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070212p
更新日期:2007-08-01 00:00:00
abstract::The adhesion of wet regenerated cellulose to colloidal complexes formed between carboxymethyl cellulose (CMC) and polyvinylamine (PVAm) was evaluated by measuring the force to delaminate pairs of regenerated cellulose membranes bound together with polyelectrolyte complex. The most important parameter was the surface c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070307r
更新日期:2007-07-01 00:00:00
abstract::Collagen fibrils were obtained in vitro by aggregation from acid-soluble type I collagen at different initial concentrations and with the addition of decorin core or intact decorin. All specimens were observed by scanning electron microscopy and atomic force microscopy. In line with the findings of other authors, lack...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070091t
更新日期:2007-07-01 00:00:00
abstract::The conformation of a single elastin-like peptide GVG(VPGVG)3 in liquid water is studied by computer simulations in the temperature interval between 280 and 440 K. Two main conformational states of the peptide can be distinguished: a rigid conformational state, dominating at low temperatures, and a flexible conformati...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070233j
更新日期:2007-07-01 00:00:00
abstract::An underwater bioadhesive generally comprises a multiprotein complex that provides a molecular basis for self-assembly. We report here a new class of self-assembling peptide inspired by a 20 kDa barnacle cement protein. Studies on the chemically synthesized 24-residue peptide have revealed that (1) it underwent irreve...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0612236
更新日期:2007-06-01 00:00:00
abstract::An injectable, heparin-based hydrogel system with the potential to be gelled with cells was developed. First, heparin was modified to have thiol groups by the modification of carboxylic groups of heparin with cysteamine using carbodiimide chemistry. Thiol functionalization of heparin carboxylic groups was controlled f...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0701189
更新日期:2007-06-01 00:00:00
abstract::A new method to form colloidally stable oligosaccharide-grafted synthetic polymer particles has been developed. The oligosaccharides, of weight-average degree of polymerization approximately 38, were obtained by enzymatic debranching of amylopectin. Through the use of a cerium(IV)-based redox initiation process, oligo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061119o
更新日期:2007-06-01 00:00:00
abstract::Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0609691
更新日期:2007-05-01 00:00:00
abstract::The effect of increasing water composition on the rheological and microstructural behavior of a ternary cellulose acetate (CA)/N,N-dimethylacetamide (DMA)/water system is examined. Addition of water to the CA/DMA system results in enhanced steady shear viscosity and dynamic viscoelastic properties and ultimately to ph...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0611681
更新日期:2007-05-01 00:00:00
abstract::Partially benzylamidated, amphipathic poly(gamma-glutamic acid) (BzPGA) was synthesized from poly(gamma-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). Benzylamine and PGA were heated in DMSO for 1 to 26 h at temperatures between 110 and 130 degrees C, producing derivatives of va...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0612182
更新日期:2007-05-01 00:00:00
abstract::Angiogenesis has long been a desired therapeutic approach to improve clinical outcomes of conditions typified by ischemia. Vascular endothelial growth factor (VEGF) has demonstrated the ability to generate new blood vessels in vivo, but trials using intravenous delivery have not yet produced clinical success. Localize...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061211k
更新日期:2007-05-01 00:00:00
abstract::The nature of the hydration of proteins and the subsequent implications for functionality is a matter of importance in both pharmaceutical and food applications. Most published studies rely on the use of one technique and attempt to characterize the system. Few studies have used combinations of techniques. In this pap...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061206g
更新日期:2007-05-01 00:00:00
abstract::Antifreeze glycoproteins (AFGPs) are a subclass of biological antifreezes found in deep sea Teleost fish. These compounds have the ability to depress the freezing point of the organism such that it can survive the subzero temperatures encountered in its environment. This physical property is very attractive for the cr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061044o
更新日期:2007-05-01 00:00:00
abstract::To provide for prolonged, site-specific delivery of basic fibroblast growth factor (bFGF) to the grafted skin in a convenient manner, biodegradable chitosan-gelatin microspheres containing bFGF were fabricated and incorporated into a porous chitosan-gelatin scaffold in this study. The microspheres are an integral part...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061025e
更新日期:2007-05-01 00:00:00
abstract::Electrospun natural polymer membranes were fabricated from collagen or gelatin coated with a bioactive recombinant fragment of perlecan, a natural heparan sulfate proteoglycan. The electrospinning process allowed the facile processing of a three-dimensional, porous fibril (2-6 microm in diameter) matrix suitable for t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061003s
更新日期:2007-04-01 00:00:00